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3.2.2 Intra-articular therapies Intra-articular (IA) therapies represent a key component of localized pharmacologic management in OA, particularly for patients who exhibit inadequate response to oral medications or are contraindicated for systemic therapy

Nitric oxide released from endothelial cells stimulates soluble guanylyl cyclase in vascular smooth muscle cells to promote vasodilation

Reconstituted peptide in aqueous solution is vulnerable to oxidation, hydrolysis at elevated temperatures, and microbial growth

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