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TLR4 belong to the family of patter recognition receptors (PRRs) and is expressed in several immune cells, such as monocytes, macrophages, and Kupffer cells, but also endothelial cells, adipocytes, and hepatocytes

doi: 10.3389/fendo.2026.1788698 Received 15 January 2026 Revised 30 January 2026 Accepted 13 February 2026 Published 03 March 2026 Volume 17 - 2026 Edited by Ploutarchos Tzoulis, University College London, United Kingdom Reviewed by Lai San Tham, Eli Lilly, United States Updates Copyright 2026 Alhazmi and le Roux