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The atherosclerosis mouse model was was induced as follows: ApoE / mice were fed a high-fat diet for 12 weeks, and the successful establishment of the AS model was confirmed by isolating arteries for ORO staining

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The study found no significant differences in systemic side effects between routes, but noted that injection site reactions were the leading cause of treatment discontinuation (3% of injectable users versus 1% of oral users discontinuing due to GI upset)