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258 , L30812 (1990)

In this review, we will discuss the spread of cancer cells through the lymphatic system, the roles of TDLNs in metastasis and anti-cancer immune responses, and the therapeutic opportunities and challenges in targeting LN metastasis

For example, ROS is produced in several ways in the mitochondria, and succinate oxidation is one of the ways to generate ROS during NAD-linked substrates, such as coupled respiration with succinate in complex I via reverse electron transfer from complex II to I

"Randomisation" prevents bias in who receives treatment