In addition to its proven use in hematologic malignancies, L-ASNase has been further investigated as an anti-tumor therapy for solid tumors in other cancer series including ovarian, breast and melanoma cancers
Here we ask if allosteric activation of the hepatocyte growth factor (HGF) cascade via Dihexa, a small molecule drug candidate, can protect hair cells from aminoglycoside toxicity
For patients in South Florida, the heat outside the refrigerator is an especially important factor: a peptide vial left on a counter in a Doral kitchen during summer is exposed to ambient temperatures that can reach the mid-80s Fahrenheit or higher, which meaningfully accelerates degradation for any reconstituted solution left out during injection preparation
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Using two incretin-based compounds simultaneously would create overlapping receptor activation at the GLP-1 and GIP sites, dramatically increasing side effect risk without proportional efficacy gains