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[1] [2] The most commonly reported side effects in clinical trials were gastrointestinal, including nausea (occurring in 12-29% of patients), diarrhea, vomiting, constipation, and abdominal discomfort

Foaming can denature the peptide

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Recent research on improving the stability of DPP-4 inhibitors and peptidomimetics through structural modifications aims to prolong pharmacological activity [18]