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Hyperglycaemia (as a marker of defective glucose homeostasis) is a fundamental feature linked to retinopathic, neuropathic and nephropathic complications, and a contributing risk for associated morbidities, particularly cardiovascular diseases

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2 GLP-1 in regulating immune system 2.1 The role of GLP-1 in innate immune cells Recent studies have demonstrated that GLP-1 and its analogues exert regulatory functions in innate immune cells, especially macrophages