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Furthermore, studies on serum from SZ patients showed elevated levels of polyamine oxidase (the enzyme responsible for degrading PAs) (96, 97), while the activities of three enzymes involved in PA synthesisornithine aminotransferase, antizyme inhibitor 1 (AZIN1), and ornithine cyclodeaminase were found to be reduced in the prefrontal cortex of both treated and untreated patients (98), ultimately potentially leading to disrupted polyamine homeostasis

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Sulforaphane possesses anti-inflammatory characteristics by decreasing TNF- and IL-6 levels, inhibiting COX-2 expression, TLR4 oligomerization, TLR4/MyD88 pathway and blocking the degradation of IL-1R-associated kinase-1, NF-B, and IFN regulatory factor 3 activation (227, 228)

Both the ADA and the World Health Organization (WHO) have adopted fasting blood glucose (FBG), 2-hour postprandial blood glucose (2-h PG), and random blood glucose levels as diagnostic criteria for diabetes mellitus

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