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Glucagon itself generally raises glucose, but potent incretin-based therapies can lower glucose substantially, especially when combined with insulin or sulfonylureas

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Within hours: Mood, irritability and sleep improves Within a day: Fatigue lessens and energy is boosted Within a week: Brain fog lifts, numbness / pins and needles start to remit Within 2 weeks: Strength may return to muscles and joints Within a month: Strength and grip improves, pains in hands and feet remit, fertility cycles normalise, thyroid and cortisol hormones normalise