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4.2 Modulation of cellular signalling pathways 4.2.1 Interference with oncogenic pathways by lipid peroxidation (LPO) products Lipid peroxidation (LPO) products, which are reactive aldehydes like 4-hydroxynonenal (4-HNE) and malondialdehyde (MDA), are formed as a result of oxidative stress in cells

The PREDIMED trial, which enrolled thousands of older adults at cardiovascular risk, demonstrated that MD adherence may improve memory and executive function and potentially delayed progression to mild cognitive impairment (204)