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Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity

Minimize air exposure by using the smallest gauge needle practical (typically 2527 gauge for peptide withdrawal) and avoid injecting excess air into the vial when equalizing pressure

Monitor your levels closely and speak with your provider about lowering doses of those drugs if needed

Acta Haematol

These cases underscore the ongoing need for vigilance in postmarketing surveillance and raise important questions regarding the full spectrum of tirzepatide's tolerability