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In such cases, people who have come off these medications have been able to keep the weight off

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Both medications mimic hormones involved in appetite regulation

This triggers several beneficial effects: it stimulates insulin release when blood sugar levels rise, reduces the amount of glucose the liver produces, and slows down digestion so glucose enters the bloodstream more gradually

(13) Thus, as GLP-1 receptor agonists promote weight loss and enhance metabolic function, they could alter the secretion of osteogenic cytokines and adipokines to promote bone formation and resorption