Both p53 TAD PEP and CAND showed limited efficacy in inducing cell death in both dividing and senescent cells (Figure
Hashemian, L., Sarhangi, N., Afshari, M., Aghaei Meybodi, H
5.1 Iron chelators and iron modifiers Iron chelators and modifiers effectively inhibit cellular ferroptosis by regulating the expression and activity of iron transporters and storage proteins, including transferrin and its receptor (TfR1), ceruloplasmin, ferroportin, divalent metal transporter 1 (DMT1), and other membrane iron transport proteins ( 2+ exists in the form of a labile iron pool and binds to low molecular weight compounds such as GSH ( To reduce intracellular Fe 3+ levels and prevent its conversion to Fe 2+ , iron chelators are widely employed
10.1016/j.chembiol.2008.02.010 116 YangX.LiY.PengY.ChangY.HeB.ZhangT.et al (2025)
The need of the hour is to conduct large scale studies to elucidate the role of glutathione in skin diseases