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(DOCX) Acknowledgments The authors would like to thank the doctors and staff of BMUfor their support in collecting specimens

in global PAT exposures should not be underestimated

These therapeutic effects appear to be mediated through curcumins modulation of key neuromodulators, with particularly noteworthy differential regulation observed between brain and gut tissues: while BDNF and phosphorylated CREB (p-CREB) levels increased in hippocampal tissue, their expression decreased in colonic tissues (Yu et al., 2015)