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The primary cause of glucotoxicity is insulin resistance, which arises from defective islet cell function and damage caused by reduced insulin mRNA expression, associated with diminished transcription or activity of transcription factors involved in insulin production (Mota et al., 2016)

Notably, Bifidobacterium, Lactobacillus, Akkermansia , and certain butyrate-producing bacteria play pivotal roles in the gut-brain axis

Observed effects are dependent on concentration, cellular context, and experimental design, and are used to investigate molecular mechanisms rather than defined physiological outcomes

Implications cliniques de la dcouverte dune hypervitaminmie B12 en mdecine interne

Lewis DA, Sherman BM