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Following initiation of treatment, the bone marrow begins producing normal-sized red cells relatively quickly a reticulocyte response is typically seen within one to two weeks
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The peptide has never cleared a Phase III clinical trial, no sponsor has filed a New Drug Application, and FDA has never issued an approval letter for any formulation of AOD-9604 for any condition
In these patients, administration of an NSAID may cause a dose-dependant reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal failure
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