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In support of this observation, a magnetic resonance spectroscopic (MRS) study revealed elevation of glutamate/glutamine signal in the thalamus of bipolar depressed patients (140)

Inhibition of glutamine formation and retention in rat brain slices by ouabain (Benjamin, Regardless of detailed mechanisms involved, ATP requirement for glutamine synthesis and ammonia uptake in astrocytes and for glutamine (or GABA) uptake in neurons makes neuronal transmitter supply from astrocytes an approximately twothree times more expensive process than neuronal production or uptake from the extracellular fluid would have been

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Rimegepant Therapeutic Indication: Acute treatment of migraine and preventive treatment of episodic migraine