The populations studied ranged in size from 3297 (SUSTAIN-6) to 14,752 (EXSCEL), were of similar age (mean age was 64.0 1.97 years), 37,117 were male (62.8%), and the median duration of follow-up ranged from 1.3 to 5.4 years
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Similar to the actions of oxytocin in the uterus to stimulate contractions during delivery, milk-ejection from breast tissue occurs due to positive feedback
(iv) introducing random error to all continuous variables, with a tolerance range decided in advance for each variable
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