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Other findings included: Gallbladder issues (especially with rapid weight loss) Pancreatitis (rare, with unclear causality) Thyroid C-cell hyperplasia (in animals, not seen in humans) Lean mass lossup to 40% of weight lost may be muscle in older adults None of these derailed regulatory approvals

Thus, as CoA becomes limiting, lipids could become the preferred energy source leading to the lower RER observed

To adjust for significant covariate effects (as applicable) in the experimental design the R package, DESeq2 (v.1.24.0) 67 was used to test for significant differences

AC, acute cholecystitis