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Cagrilintide is a newer long-acting amylin analogue - in a phase 2 trial, once weekly cagrilintide resulted in a dose-dependent WL between 6 and 10.8% compared to 9% with liraglutide 3 mg and 3% with placebo [87]

The 1.0 mg to 1.7 mg and 1.7 mg to 2.4 mg transitions are smaller relative increases, but cumulative GI adaptation means they usually feel less dramatic than earlier escalations

People taking semaglutide typically see lowered A1c levels, which measure average blood sugar over three months

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The study protocol for the proteomic analyses was approved by the ethics committee for the Region of Southern Denmark (number H-21046833