However, the term Metabolic Syndrome has become commonly used since its inception by the Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) in 2001 [1]
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Lidocaine is extensively metabolized in the liver, so drugs that decrease hepatic blood flow (e.g., propranolol) or inhibit CYP1A2/CYP3A4 (e.g., fluvoxamine, ketoconazole, clarithromycin) may elevate systemic concentrations and increase the risk of central nervous system or cardiovascular toxicity
Determining the optimal dose-response curve is a critical part of the research
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