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GRase was another key node in cluster 4, which played a role of bridge between clusters

These agents require careful dose titrations due to their adverse drug event (ADE) profile, which commonly includes nausea and vomiting

NLRP3 inflammasome is formed due to hyperglycaemia and hyperlipidaemia, which promote pro-inflammatory cytokines by upregulating IL-1, IL-6 and IL-18, leading towards exacerbation of DCM pathology (134)

CELLg8 Liposomes have been clinically proven to have better absorption, increased efficacy, and no side effects

Additionally, studies in mice have shown higher liver and kidney expression of Selenop in females than that in males (Schomburg et al., 2007), so SELENOP/LRP8-brain Se uptake pathway may also exert sex-dependence