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Both of these heavy metalbased agents are extensively documented to induce severe oxidative stress and disrupt cellular glutathione levels [72, 73]

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This effect was blocked by specific D4-inhibition with L-745,870 and confirmed in Drd4 / mice, which showed profound age-dependent reduction in T h 2 inflammation with altered allergen exposure response in the lung of neonatal animals (Wang, Cohen et al., 2019)