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Conversely, FGF-21 deficiency exacerbates liver damage in rodents fed high-fat, high-sugar, and alcohol-rich diets [279]

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doi: 10.1016/j.mcn.2015.10.005 155 XuWYangYYuanGZhuWMaDHuS

Consistent with the notion that GSH per se does not regulate mTORC1 and the ISR, depletion of intracellular GSH exacerbated the loss of mTORC1 signaling upon cystine deprivation, but was without observable effect in the presence of cystine (Fig

Although L-cysteine is a minor scavenger of oxidative stress, its most important role is reviving glutathione, one of the most powerful antioxidants in the body