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The resulting metabolic disturbances cause myocardial lipid accumulation, mitochondrial dysfunction, and ROS accumulation, manifesting as cardiac hypertrophy, reduced contractile function, and impaired exercise tolerance, establishing TMAVA as an independent cardiovascular toxic molecule

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These data may further support classification for diagnosis and clinical management and we note that the machine learning model engineered for this purpose did not contain explicit information about the binding of either Na + or carnitine 11

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However, its estimated that between 3 and 10 million people actually suffer from an overactive thyroid or hyperthyroidism