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The Fenton reaction describes how ferrous ions (Fe 2 ) react with hydrogen peroxide (HO) to produce highly reactive hydroxyl radicals (OH), which contribute to oxidative stress: This reaction is a major source of oxidative damage in biological systems, as the hydroxyl radicals can attack lipids, proteins, and DNA

OShea AE, Valdera FA, Ensley D, Smolinsky TR, Cindass JL, Bohan PMK, Hickerson AT, Carpenter EL, McCarthy PM, Adams AM, Vreeland TJ (2022) Immunologic and dose dependent effects of rapamycin and its evolving role in chemoprevention

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Allosteric modulation of endogenous metabolites as an avenue for drug discovery