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Of these drugs, glucagon-like peptide 1 receptor (GLP-1R) agonists are more effective and have fewer side effects

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This is mechanistically different from dieting: dietary restriction alone triggers compensatory hormonal responses (elevated ghrelin, suppressed leptin, reduced NEAT by 200400 calories/day) that work against weight loss over time

Sustained management of digestive symptoms on Saxenda requires a comprehensive, individualised approach that balances therapeutic benefit with quality of life