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The prognostic role for hs-cTn assays in HFpEF also has a sex-specific concern, as the more sensitive hs-cTnI assay appears to be a better predictor of outcome in men than in women ( Figure 2 ).43 When combining the mechanistic data with the described associations of hs-cTn with adverse clinical outcomes, it appears reasonable to proclaim hs-cTn as a surrogate for a clinically meaningful HFpEF endpoint

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