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Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, et al

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Caution must be exercised in prescribing these agents in patients with an increased risk of side effects, such as excessive weight, comorbid severe depression, dependence issues and compromised respiratory reserve, particularly in combination with opioids

B-12 supports healthy sleep cycles, which can lead to deeper rest and easier mornings