Without maintenance, the improvement typically diminishes gradually over 24 months as natural melanin production resumes
Clin Geriatr Med
Skeletal muscle and bone changes can most probably be explained by the abnormal movements of ataxic mice [124, 125]
Ling H, Pickard K, Ivan C, Isella C, Ikuo M, Mitter R, Spizzo R, Bullock MD, Braicu C, Pileczki V, Vincent K, Pichler M, Stiegelbauer V, Hoefler G, Almeida MI, Hsiao A, Zhang X, Primrose JN, Packham GK, Liu K, Bojja K, Gaf R, Xiao L, Rossi S, Song JH, Vannini I, Fanini F, Kopetz S , Zweidler-McKay P, Wang X, Ionescu C, Irimie A, Fabbri M, Lanza G, Hamilton SR, Berindan-Neagoe I, Medico E, Mirnezami AH, Calin GA, Nicoloso MS
Starting with 50 mg/kg daily for the first week and transitioning to 25 mg/kg three times weekly until the third month, this regimen aimed to enhance enzymatic activity during early graft healing