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13 In the CVOTs, GLP-1 RAs were associated with a reduction in new-onset HF among patients with cardiovascular risk factors, but neutral effects were observed on HF events among patients with already diagnosed and stable HF

doi: 10.1080/13543784.2020.1763302 48 MaruyamaTMiyamotoYNakamuraTTamaiYOkadaHSugiyamaEet al

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Future investigations need to provide details about the crosstalk between NO/GSH and the endocrine function of muscle since the production and release of myokines place this organ central to the physiology of metabolic regulation