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It should be noted that the timing (before, during or after stroke induction), mode (i.v., i.c.v., i.p.), and dose (low and high doses) of drug administration to different animals (gerbil, mice, rat) might exert different effects against stroke as we have described it above
9 , e1003401 (2013)
Berberine's quaternary ammonium structure and hydrophilic nature present significant challenges for passive skin penetration, raising questions about whether these patches can achieve therapeutically relevant systemic concentrations
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