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Occasional digestive upset can occur even in long-term users, typically triggered by dietary indiscretions, stress, or other factors unrelated to the medication

Gene Ther (2002) 9:86778

Hybrid models, like those pursued by Empower and others, could become the norm

High insulin levels in the post-prandial state decrease hepatic VLDL production, favoring chylomicron-mediated delivery of dietary lipids to the periphery [111], but the selective hepatic insulin resistance in patients with NAFLD allows insulin to stimulate DNL without inhibiting VLDL production [118]