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Allergens or toxins in the urine are thought to cause the bladder walls to become sensitized to increased mast cells.[ref][ref][ref] Vulvodynia and mast cell activation: Vulvodynia is a chronic genital pain condition that includes an increased number of mast cells
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Thus, CD14 could be a possible molecular target for ex vivo genetic modification prior to cell transplantation to increase the therapeutic impact of microglia/hematopoietic cell transplantation
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