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Hypertrophy + hyperplasia Animal-model research shows IGF-1 LR3 drives both fibre growth (hypertrophy) and new fibre formation (hyperplasia) - distinct from most anabolic agents

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In two-thirds of cases, the red cells are abnormally sensitive to osmotic lysis when incubated in hypotonic salt solutions, which causes the influx of water into spherocytes with little margin for expansion

By comparison, the rate constant for thiol oxidation by superoxide (O 2 ) has been estimated to be in the range of 100 M 1 s 1 ( 2 -concentration is restricted by superoxide dismutase to approximately 10 10 M ( in vitro to O 2 -that was steadily produced by xanthine oxidase (2 M/min over a period of 4 h)