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2.1.2 Molecular and cellular mechanisms underlying the pathogenesis of AD Amyloid plaques arise from the aggregation of A peptides, particularly A4 2 , which is harmful due to its tendency to form plaques and resist dissolving (Jarrett et al., 1993)

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doi: 10.1016/j.bbamcr.2006.08.039 44 TurrensJFBoverisA

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Elamipretide: a review of its structure, mechanism of action, and therapeutic potential