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It was further revealed that UA inhibited ERK, JNK, and Akt phosphorylation but had no influence on the NF-B p65 and p38-MAPK pathways

investigating if our results hold true in other species

Although efforts were made to enhance transparency in the literature selection and to prioritize high-quality evidence, the absence of formal risk-of-bias assessment and quantitative synthesis should be considered when interpreting the conclusions

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A subsequent larger RCT (n=72) confirmed these findings, showing improvements in gait speed, grip strength, exercise capacity, waist circumference, and systolic blood pressure (Kumar et al., J Gerontol A Biol Sci Med Sci, 2023) [21]