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In controlled laboratory systems, investigators employ in vitro and animal injury paradigms such as skin wound repair , tendon and ligament damage , muscle degeneration , gastrointestinal inflammation , pulmonary injury , and neuroinflammatory conditions to explore peptideassociated signaling effects (9,10)

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1 Numerous medications have been associated with CI, including constipation-inducing drugs (eg, opioids, muscarinic antagonists), diuretics (eg, furosemide), nonsteroidal anti-inflammatory drugs, illicit drugs (eg, cocaine), digoxin, hormonal therapies (eg, combined oral contraceptives), and laxatives

Additionally, leveraging national or international databases would allow for the selection of individuals with chronic glaucoma and rapid progression, enhancing the efficiency of the research (101)