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Beyond BBB disruption, peripheral inflammatory factors or chemokines activate perivascular macrophages through receptors on astrocytes and vascular endothelial cells, generating inflammatory mediators

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Anxiety can deepen the same loop, since excessive worry often brings muscle tension, restlessness, and trouble concentrating, symptoms detailed by the Mayo Clinic in its guide to generalized anxiety disorder

Of the participants in the CT group, one man experienced mild gingival bleeding and one woman had premature menstruation during the fasting period

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