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When the vessel is injured, VSMCs are converted to a highly proliferative synthetic phenotype, accelerating VSMC migration and proliferation and the secretion of extracellular matrix molecules, thereby accelerating AS progression (Verdeguer et al., 2007) and Wnt signaling pathways (Zhuang et al., 2016)

This concentration allows precise dosing in 100mcg increments using standard insulin syringe markings (each 0.02mL or 2-unit increment equals 100mcg), which is critical for research protocols involving dose titration in the 250-1000mcg range

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most brightening serums use one or the other