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Our data support a dual-axis model in which a pharmacologic trigger interacts with modulation of the immune-tolerance threshold, suggesting that ICI exposure may lower immune tolerance and thereby amplify subsequent drug-induced, T cellmediated immune responses

Mousapour et al., Efficacy and Safety of Acetylcysteine for the Prevention of Liver Injury in Covid-19 Intensive Care Unit Patients Under Treatment with Remdesivir: A Double-Blind, Placebo-Controlled Randomized Clinical Trial: Prevention of liver injury in severe Covid-19 pneumonia, Gastroenterology and Hepatology from Bed to Bench, doi:10.22037/ghfbb.v15i3.2565

The supernatants were then removed and the formazan dye was dissolved in dimethyl sulfoxide (DMSO)

doi:10.1016/0076-6879(95)51107-5

Kohno T, Urao N, Ashino T, Sudhahar V, McKinney RD, Hamakubo T