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The explanation is that GLP-1 likely affects heart rate indirectly, through autonomic nervous system modulation rather than direct cardiac effects

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Secondary care treatments NICE recommended that patients with confirmed varicose veins and truncal reflux that is causing troublesome symptoms such as bleeding should be referred to a vascular specialist

A landmark trial in the New England Journal of Medicine found that patients maintaining GLP-1 therapy preserved 80% of their weight loss two years into treatment, while those who stopped regained most losses

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