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The usual concern with regards to treatment with IGF-1 has historically been hypoglycaemia, however in the trials done so far it has not always occurred and had been lessened when administered with mealsit was also usually connected to an appearance in a loss of appetite [264, 286]

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17,18 A post hoc analysis of LOOK AHEAD trial data found that participants who achieved at least a 10% body weight loss in the first year had a 21% lower rate of major adverse cardiac events

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