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In contrast, truncation of the first two residues of exendin-4 does not significantly alter its affinity, but does lower potency for cAMP signalling by approximately 200-fold 2325

As the list of potential benefits of GLP-1 grows, Drucker warns that the buzz must be balanced with caution and scientific rigour

Gupta S, Bansal R, Gupta S, Jindal N, Jindal A

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Glucagon-like peptide 1 (GLP-1) is an incretin 30 amino-acid peptide hormone produced in hindbrain neurons and in specialized enteroendocrine cells (L cells) in the distal small and large intestines that is released after food intake [23, 24]