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India's National Non-Communicable Disease Monitoring Survey, cited in the 2024 ICMR-NIN Dietary Guidelines for Indians, found that 98.4% of adults fall short of the recommended fruit and vegetable intake averaging just 1.7 servings a day

Mol Psychiatry 2016

Social Cognit Affective Neurosci 2016;11:899906

In this study, the correlation between the CLOCK gene and the BMAL1 gene was not high, which was consistent with the view that different parts of the circadian clock system linked to different functions as circadian oscillators ( CLOCK, PER1, PER2, CRY3, NRLD2 ) showed the difference of expression oscillation in the pituitary of GH transgenic and wild type coho salmon, which indicated that the GH gene might have a regulatory effect on the expression of pituitary clock genes

However, its not yet understood whether synephrine alone or combined with other stimulants causes these symptoms ( Summary Bitter orange contains a compound called synephrine that may boost metabolism and encourage weight loss