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Ubiquitination and degradation of p61 by the E3 ubiquitin ligase TRIM21 leads to failure of p61-mediated Nrf2 activation, which reduces the antioxidant capacity of tumor cells and makes them more prone to ferroptosis

Step 1: Check Your Diet and Medications Have you have recently eaten brightly coloured red foods like beetroot or berries

Ness-Abramof R, Nabriski DA, Braverman LE, Shilo L, Weiss E, Reshef T, et al

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This article explains how each agent works, what the current evidence shows, the safety considerations patients should understand, and how to access emerging obesity treatments safely through regulated NHS and clinical trial pathways