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Evidence suggests that favoring sustained G protein signaling over arrestin-driven internalization can prolong cyclic AMP production and insulin secretion, which has made biased agonism a deliberate goal in molecular design rather than an academic curiosity
This project used the Hillman Animal Facility, the Cancer Genomics Facility, the Tissue and Research Pathology/Pitt Biospecimen Core, the Biostatistics Core and the Cancer Bioinformatics Services, which are supported in part by award P30CA047904
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