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Participants in the semaglutide group achieved a weight loss of at least 5%, 10%, or 15%, and improvements in secondary endpoints, such as waist circumference, blood pressure, and lipid levels, compared to the placebo group

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Unlike many drugs, semaglutide is metabolized through proteolytic degradation into smaller peptides and amino acids that resemble those naturally occurring in the body, which are then excreted primarily through the kidneys

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