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In the UK, GLP-1 receptor agonists licensed specifically for weight management include semaglutide 2.4 mg (Wegovy) and liraglutide 3.0 mg (Saxenda)

Although the impact of GLP-1RAs on CD outcomes is not well defined, some preclinical data suggest that GLP-1RAs have anti-inflammatory and gut barrier-protective effects

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Under hypoxic conditions, hypoxia-inducible factor-1 alpha (HIF-1) fails to undergo ubiquitination and degradation, then undergoes nuclear translocation to bind to promoters on the vascular endothelial growth factor gene, finally increasing the expression of HIF-1 and VEGF in endometriotic lesions

Beckers lab is addressing that gap by mapping where these drugs act in the brain and how they influence reward and motivation circuits, including how signals from the gut may shape craving and behavior