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NE serves as the principal elastin-degrading enzyme but extends well beyond this role to effectively degrade collagen, fibronectin, and various proteoglycans ( Beyond its proteolytic function, PR3 serves as the major autoantigen in anti-neutrophil cytoplasmic antibody-associated vasculitis, conferring special relevance in autoimmune diseases ( CatG exhibits distinctive dual biological characteristics, effectively degrading various extracellular matrix proteins while possessing significant antimicrobial activity

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Leptin levels fell during weight loss and increased brain activity in areas involved in emotional, cognitive, and sensory control of food intake